Gardel Lab Publications

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Highly flexible PEG-LifeAct constructs act as tunable biomimetic actin crosslinkers. D. Jorgenson T, D. Baboolall K, Suarez C, R. Kovar D, L. Gardel M, J. Rowan S. Soft Matter. 20(5): 971–7. 2024. (PMID: 38190228) (pdf

Machine learning interpretable models of cell mechanics from protein images. Schmitt MS, Colen J, Sala S, Devany J, Seetharaman S, Caillier A, Gardel ML, Oakes PW, Vitelli V. Cell 2024, 187 (2): 481-494.e24 (PMID: 36911285) (pdf)

Limiting Pool and Actin Architecture Controls Myosin Cluster Sizes in Adherent Cells. Chou WH, Molaei M, Wu H, Oakes PW, Beach JR, Gardel ML. Biophys J 2024, 123(2): 157-171 (PMID: 37333106) (pdf)


Motor crosslinking augments elasticity in active nematics. Redford SA, Colen J, Shivers JL, Zemsky S, Molaei M, Floyd C, Ruijgrok PV, Vitelli V, Bryant Z, Dinner AR, Gardel ML. Soft Matter. 20(11): 2480–90. 2024. (PMCID: PMC10491317)  (PDF) 

Learning to learn by using nonequilibrium training protocols for adaptable materials. Falk MJ, Wu J, Matthews A, Sachdeva V, Pashine N, Gardel ML, Nagel SR, Murugan A. Proc Natl Acad Sci U S A 2023, 120 (27): e2219558120 (PMID: 37364104) (pdf)

Cracked actin filaments as mechanosensitive receptors. Zsolnay V, Gardel ML, Kovar DR, Voth GA. [Preprint] bioRxiv 2023, 2023.06.26.546553 (PMID: 37425801) (pdf)

Epithelial tissue confinement inhibits cell growth and leads to volume-reducing divisions. Devany J, Falk MJ, Holt LJ, Murugan A, Gardel ML. Dev Cell 2023, 58(16): 1462-1476.e8. (PMID: 37339629) (pdf)

Direct detection of deformation modes on varying length scales in active biopolymer networks. Stam S, Gardel ML, Weirich K. [Preprint] bioRxiv 2023 (PMID: 37292666) (pdf)Measuring response functions of active materials from data. Molaei M, Redford SA, Chou W, Scheff D, de Pablo JJ, Oakes PW, Gardel ML. Proc Natl Acad Sci U S A 2023, 120(42): e2305283120 (PMID: 37819979) (pdf)

Membrane tension induces F-actin reorganization and flow in a biomimetic model cortex. Sakamoto R, Banerjee DS, Yadav V, Chen S, Gardel ML, Sykes C, Banerjee S, Murrell MP. Commun Biol 2023, 6 (1): 325, 470 (PMID: 37117264) (pdf) (correction pdf)

Quantifying Strain-Sensing Protein Recruitment During Stress Fiber Repair. Seetharaman S, Sala S, Gardel ML, Oakes PW. Methods Mol Biol 2023, 2600: 169-182 (PMID: 36587097) (pdf)


TES-1/Tes and ZYX-1/Zyxin protect junctional actin networks under tension during epidermal morphogenesis in the C. elegans embryo. Lynch AM, Zhu Y, Lucas BG, Winkelman JD, Bai K, Martin SCT, Block S, Slabodnick MM, Audhya A, Goldstein B, Pettitt J, Gardel ML, Hardin J. Curr Biol 2022, 32(23): 5189-5199.e6 (PMID: 36384139) (pdf)

Catapulting of topological defects through elasticity bands in active nematics. Kumar N, Zhang R, Redford SA, de Pablo JJ, Gardel ML. Soft Matter 2022, 18: 5271-5281 (PMID: 35789364) (pdf)

Force-dependent intercellular adhesion strengthening underlies asymmetric adherens junction contraction. Cavanaugh KE, Staddon MF, Chmiel TA, Harmon RM, Budnar S, Yap AS, Banerjee S, Gardel ML. Current Biology 2022, 32(9): 1986-2000.e5 (PMID: 35381185) (pdf)

Dia1 coordinates differentiation and cell sorting in a stratified epithelium. Harmon RM, Devany J, Gardel ML. J Cell Biol 2022, 221(5): e202101008 (PMID: 35323863) (pdf)

Confluence and tight junction dependence of volume regulation in epithelial tissue. Chmiel TA, Gardel ML. Mol Biol Cell 2022, 33(11): 1-8 (PMID: 35731553) (pdf)


LIM domain proteins in cell mechanobiology. Anderson CA, Kovar DR, Gardel ML, Winkelman JD. Cytoskeleton 2021, 78(6): 303-311 (PMID: 34028199) (pdf)

Actin filament alignment causes mechanical hysteresis in cross-linked networks. Scheff DR, Redford SA, Lorpaiboon C, Majumdar S, Dinner A, Gardel ML. Soft Matter 2021, 17(22): 5499-5507 (PMID: 33989373) (pdf)

Actin bundle architecture and mechanics regulate myosin II force generation. Weirich KL, Stam S, Munro E, Gardel ML. Biophys J. 2021, 120(10): 1957-1970 (PMID: 33798565) (pdf)

Machine learning active-nematic hydrodynamics. Colen J, Han M, Zhang R, Redford SA, Lemma LM, Morgan L, Ruijgrok PV, Adkins R, Bryant Z, Dogic Z, Gardel ML, De Pablo JJ, Vitelli V. Proc Natl Acad Sci USA. 2021, 118(10): e2016708118 (PMID: 33653956) (pdf)

Cell cycle-dependent active stress drives epithelia remodeling. Devany J, Sussman DM, Yamamoto T, Manning ML, Gardel ML. Proc Natl Acad Sci USA. 2021, 118(10): e1917853118. (PMID: 33649197) (pdf)

Spatiotemporal control of liquid crystal structure and dynamics through activity patterning. Zhang R, Redford SA, Ruijgrok PV, Kumar N, Mozaffari A, Zemsky S, Dinner AR, Vitelli V, Bryant Z, Gardel ML, de Pablo JJ. Nature Materials. 2021, 20: 875-882 (PMID: 33603187) (pdf)


Evolutionarily diverse LIM domain-containing proteins bind stressed actin filaments through a conserved mechanism. Winkelman JD, Anderson CA, Suarez C, Kovar DR, Gardel ML. Proc Natl Acad Sci USA. 2020, 117(41): 25532-25542 (PMID: 32989126) (pdf)

Adaptive viscoelasticity of epithelial cell junctions: from models to methods. Cavanaugh KE, Staddon MF, Banerjee S, Gardel ML. Curr Opin Genet Dev. 2020, 63: 86-94  (PMID: 32604032)(pdf)

Dynamin regulates the dynamics and mechanical strength of the actin cytoskeleton as a multifilament actin-bundling protein. Zhang R, Lee DM, Jimah JR, Gerassimov N, Yang C, Kim S, Luvsanjav D, Winkelman J, Mettlen M, Abrams ME, Kalia R, Keene P, Pandey P, Ravaux B, Kim JH, Ditlev J, Zhang G, Rosen MK, Frost A, Alto NM, Gardel ML, Schmid SL, Svitkina TM, Hinshaw JE, Chen EH. Nat Cell Biol. 2020, 22, 674-688 (PMID: 32451441) (pdf)

Tuning shape and internal structure of protein droplets via biopolymer filaments. Scheff DR, Weirich KL, Dasbiswas K, Patel A, Vaikuntanathan S, Gardel ML. Soft Matter. 2020, 16: 5659-5668 (PMID: 32519715) (pdf)

Nucleation and Shape Dynamics of Model Nematic Tactoids Around Adhesive Colloids. Ludwig NB, Weirich  KL, Alster E, Witten TA, Gardel ML, Dasbiswas K, Vaikuntanathan S. J Chem Phys. 2020, 152: 084901 (PMID: 32113348) (pdf)

Optogenetic Control of RhoA to Probe Subcellular Mechanochemical Circuitry. Cavanaugh KE, Oakes PW, Gardel ML. Curr Prot Cell Biol. 2020, 86(1): e102 (PMID: 32031760) (pdf)

Tuning Molecular Motor Transport Through Cytoskeletal Filament Network Organization. Scholz M, Weirich KL, Gardel ML, Dinner AR. Soft Matter. 2020, 16: 2135-2140 (PMID: 32016200) (pdf)

RhoA Mediates Epithelial Cell Shape Changes via Mechanosensitive Endocytosis. Cavanaugh KE, Staddon MF, Munro E, Banerjee S, Gardel ML. Dev Cell. 2020, 52(2): 152-166 (PMID: 31883774) (pdf)


The Actin Cytoskeleton as an Active Adaptive Material. Banerjee S, Gardel ML, Schwarz US. Annu Rev Condens Matter Phys. 2019, 11: 421-439 (PMID: 33343823) (pdf)

High Throughput Discovery of Functional Protein Modificiations by Hotspot Thermal Profiling. Huang JX, Lee G, Cavanaugh KE, Chang JW, Gardel ML, Moellering RE. Nat Methods. 2019, 16: 894-901 (PMID: 31384043) (pdf)

Stress Relaxation in F-actin Solutions by Severing. Arzash S, McCall PM, Feng J, Gardel ML, MacKintosh FC. Soft Matter. 2019, 15: 6300-6307 (PMID: 31342050) (pdf)

Mechanosensitive Junction Remodelling Promotes Robust Epithelial Morphogenesis. Staddon MF, Cavanaugh KE, Munro EM, Gardel ML, Banerjee S. Biophys J. 2019, 117(9): 1739-1750 (PMID: 31635790) (pdf)

Cofilin Drives Rapid Turnover and Fluidization of Entangled F-actin. McCall PM, MacKintosh FC, Kovar DR, Gardel ML. Proc Natl Acad Sci USA. 2019, 116(26): 12629-12637 (PMID: 31189606) (pdf)

Self Organizing Motors Divide Active Liquid Droplets. Weirich KL, Dasbiswas K, Witten TA, Vaikuntanathan S, Gardel ML. Proc Natl Acad Sci USA. 2019, 116(23): 11125-11130 (PMID: 31113883) (pdf)


Tunable Structure and Dynamics of Active Liquid Crystals. Kumar N, Zhang R, de Pablo JJ, Gardel ML. Sci Adv. 2018, 4(10): eaat7779 (PMID: 30333990) (pdf)

Force Localization Modes in Dynamic Epithelial Colonies. Schaumann EN, Staddon MF, Gardel ML, Banerjee S. Mol Biol Cell. 2018, 29(23): 2835-2847 (PMID: 30207837) (pdf)

Partitioning and Enhanced Self-Assembly of Actin in Polypeptide Coacervates. McCall PM, Srivastava S, Perry SL, Kovar  DR, Gardel ML, Tirrell MV. Biophys J. 2018, 114(7): 1636-1645 (PMID: 29642033) (pdf)

Desmosomal Cadherin Association With Tctex-1 and Cortactin-Arp2/3 Drives Perijunctional Actin Polymerization to Promote Keratinocyte Delamination. Nekrasova O, Harmon RM, Broussard JA, Koetsier JL, Godsel LM, Fitz GN, Gardel ML, Green KJ. Nat Commun. 2018; 9:1053. (PMID: 29535305) (pdf)

Lamellipodium is a Myosin-Independent Mechanosensor. Oakes PW, Bidone TC, Beckham Y, Skeeters AV, Ramirez-San Juan GR, Winter SP, Voth GA, Gardel ML. Proc Natl Acad Sci USA. 2019, 115(11): 2646-2651 (PMID: 29487208) (pdf)

Mechanical Hysteresis in Actin Networks. Majumdar S, Foucard LC, Levine AJ, Gardel ML. Soft Matter. 2018, 14: 2052-2058. (PMID: 29479596) (pdf)

Dia1-Dependent Adhesions Are Required For Invasion By Epithelial Tissues. Fessenden TB, Beckham Y, Perez-Neut M, Ramirez-San Juan GR, Chourasia AH, Macleod KF, Oakes PW, Gardel ML. J Cell Biol. 2017, 217(2): 1-18. (PMID: 29437785) (pdf)


Interplay of Structure, Elasticity and Dynamics in Actin-Based Nematic Materials. Zhang R, Kumar N, Ross J, Gardel ML, de Pablo JJ. Proc Natl Acad Sci USA. 2017; 115(2) E124-E133;. (PMID: 29284753) (link)(pdf)

Filament Turnover Tunes Both Force Generation and Dissipation to Control Long-Range Flows In a Model Actomyosin Cortex. McFadden WM, McCall PM, Gardel ML, Munro EM. PLoS Comput Biol. 2017; 13(12):e1005811.(PMID: 29253848) (link) (pdf)

Filament Rigidity And Connectivity Tune The Deformation Modes Of Active Biopolymer Networks. Stam S, Freedman SL, Banerjee S, Weirich KL, Dinner AR, Gardel ML. Proc Natl Acad Sci USA. 2017; 114(47):E10037-E10045. (PMID: 29114058) (link)(pdf)

When Is “Enough” Enough? Suarez C, McCall PM, Gardel ML; Kovar DR. Cell Systems. 2017; 4(5):480-482. (link)

Cholesterol depletion impairs contractile machinery in neonatal rat cardiomyocytes. Hissa B, Oakes PW, Pontes B, Ramirez-San Juan GR, Gardel ML. Sci Rep. 2017; 7:43764. (PMID: 28256617) (link)(pdf)

Contact guidance requires spatial control of leading edge protrusion. Ramirez-San Juan GR, Oakes PW, Gardel ML. Mol Biol Cell; 2017.(PMID: 28228548) (link)(pdf)

Optogenetic control of RhoA reveals Zyxin-mediated elasticity of stress fibres. Oakes PW, Wagner E, Brand CA, Probst D, Linke M, Schwarz US, Glotzer M, Gardel ML. Nat Commun. 2017; 8:15817.(PMID: 28604737) (link)(pdf)

Liquid behavior of cross-linked actin bundles. Weirich KL, Banerjee S, Disbiswas K, Witten TA, Vaikuntanathan S, and Gardel ML. Proc Natl Acad Sci USA. 2017; 114(9):2131-2136.(PMID: 28202730) (link)(pdf)


Cycling State that Can Lead to Glassy Dynamics in Intracellular Transport. Scholz M, Burov S, Weirich KL, Scholz BJ, Tabei SMA, Gardel ML and Dinner AR. Phys Rev. X 2016; (6):011037. (link) (pdf)


Measuring Cell Mechanics. Gardel M & Oakes P. Colloquium Series on Quantitative Cell Biology: Vol. 3 ed. Marshall WF. Morgan & Claypool Life Sciences Publishers. 2015; DOI: 10.4199/C00137ED1V01Y201508QCB003 (Link)

Forcing cells into shape: the mechanics of actomyosin contractility. Murrell M, Oakes PW, Lenz M and Gardel ML. Nat Rev Mol Cell Biol. 2015; 16(8):486-498. (PMID:26130009) (pdf)

Model for adhesion clutch explains biphasic relationship between actin flow and traction at the cell leading edge. Craig EM, Stricker J, Gardel M and Mogilner A. Phys Biol. 2015; 12(3):035002. (PMID:25969948) (pdf)

Actin mechanics and fragmentation. De La Cruz EM and Gardel ML. J Biol Chem. 2015; 290(28):17137-44 (PMID:25957404) (pdf)

Isoforms Confer Characteristic Force Generation and Mechanosensation by Myosin II Filaments. Stam S, Alberts J, Gardel ML, and Munro E. Biophys J. 2015; 108(8):1997-2006. (PMID:25902439) (pdf)

Model-based traction force microscopy reveals differential tension in cellular actin bundles. Soiné JRD, Brand CA, Stricker J, Oakes PW, Gardel ML, Schwarz US. PLoS Comput Biol. 2015; 11(3):e1004076. (PMID:25748431) (pdf)

iBiology – Margaret Gardel: What is Cytoplasm? (iBiology) (YouTube) (iTunes)

Moving beyond molecular mechanisms. Gardel ML. J Cell Biol. 2015; 208(2):143-145. (PMID:25601400) (pdf)

Attenuation of LPS-induced Lung Vascular Stiffening by Lipoxin Reduces Lung Inflammation. Meng F, Mambetsariev I, Tian Y, Beckham Y, Meliton A, Leff A, Gardel ML, Allen MJ, Birukov KG and Birukov AA. Am J Respir Cell Mol Biol. 2015; 52(2):152-161. (PMID:24992633) (pdf)


Epithelial rotation promotes the global alignment of contractile actin bundles during Drosophila egg chamber elongation. Cetera M, Ramirez-San Juan GR, Oakes PW, Lewellyn L, Fairchild MJ, Tanentzapf G, Gardel ML, Horne-Badovinac S. Nat. Commun. 2014; 5:1-12 (PMID: 25413675) (pdf)

Cutting through the noise: the mechanics of intracellular transport. Stam S and Gardel ML. Dev Cell. 2014; 30:365-366. (PMID:25158851) (pdf)

Geometry Regulates Traction Stresses in Adherent Cells. Oakes PW, Banerjee S, Marchetti CM and Gardel ML. Biophys J. 2014; 107(4):825-833. (PMID:25140417) (pdf)
(In the same issue see New and Notable: Work and Tension: New Evidence that Adherent Cells of Same Area Do the Same Work Independent of Stiffness and Focal Adhesions. Pok S & Jacot JG.)

Protrusive Activity Guides Changes in Cell-Cell Tension during Epithelial Cell Scattering. Maruthamuthu V and Gardel ML. Biophys J. 2014; 107(3):555-563. (PMID:25099795) (pdf)

Stressing the Limits of Focal Adhesion Mechanosensitivity. Oakes PW and Gardel ML. Curr Opin Cell Biol. 2014; 30:68-73. (PMID:24998185) (pdf)

Arp2/3 Inhibition Induces Amoeboid-Like Protrusions in MCF10A Epithelial Cells by Reduced Cytoskeletal-Membrane Coupling and Focal Adhesion Assembly. Beckham Y, Vasquez RJ, Stricker J, Sayegh K, Campillo C and Gardel ML. PLoS ONE. 2014; 9(6):e100943. (PMID:24967897) (pdf)

Actomyosin Sliding is Attenuated in Contractile Biomimetic Cortices. Murrell M and Gardel ML. Mol Biol Cell. 2014; 25(12):1845-53. (PMID:24760970) (pdf)

Reconstitution of Contractile Actomyosin Arrays. Murrell M, Thoresen T and Gardel ML. Methods Enzymol 2014; 540:265-82. (PMID:24630112) (pdf)

Determinants of Fluid-like Behavior and Effective Viscosity in Cross-linked Actin Networks. Kim TY, Gardel ML and Munro E. Biophys J. 2014; 106(3):526-534. (PMID:24507593) (pdf)

Liposome Adhesion Generates Traction Stress. Murrell MP, Voituriez R, Joanny J-F, Nassoy P, Sykes C and Gardel ML. Nat Phys. 2014; 10:163-169. (link) (pdf)


Distribution of Directional Change as a Signature of Complex Dynamics. Burov  S, Tabei SMA, Huynh T, Murrell MP, Philipson LH, Rice SA, Gardel ML, Scherer NF and Dinner AR. Proc Natl Acad Sci USA. 2013; 110(49):19689-19694. (PMID:24248363) (pdf)

Endothelial Barrier Disruption and Recovery is Controlled by Substrate Stiffness. Birukova AA, Tian X, Cokic I, Beckham Y, Gardel ML and Birukov KG. Microvasc Res. 2013; 87:50-57. (PMID:23296034) (pdf)

Myosin II-Mediated Focal Adhesion Maturation Is Tension Insensitive. Stricker J, Beckham Y, Davidson MW and Gardel ML. PLoS ONE. 2013; 8(7):e70652. (PMID:23923013) (pdf)

Actin assembly factors regulate the gelation kinetics and architecture of F-actin networks. Falzone TT, Oakes PW, Sees J, Kovar DR and Gardel ML. Biophys J. 2013; 104(8):1709-1719. (PMID:23601318) (pdf)

Thick filament length and isoform composition determine self-organized contractile units in actomyosin bundles. Thoresen T, Lenz M and Gardel ML. Biophys J. 2013; 104(11):655-665. (PMID: 23442916) (pdf)

Materials science: Synthetic polymers with biological rigidity. Gardel ML, Nature. 2013; 493:618-619. (PMID: 23354043) (pdf)

Observation and characterization of the vestige of the jamming transition in a thermal three-dimensional system. Caswell TA, Zhang Z, Gardel ML and Nagel SR, Phys Rev E. 2013; 87(1):012303. (PMID: 23410327) (pdf)


F-actin buckling coordinates contractility and severing in a biomimetic actomyosin cortex. Murrell MP and Gardel ML, Proc Natl Acad Sci USA. 2012; 109(51):20820-20825. (PMID: 23213249) (pdf)

Stiffness-controlled three-dimensional extracellular matrices for high-resolution imaging of cell behavior. Fischer RS, Myers KA, Gardel ML and Waterman CM, Nat Protoc. 2012; 7(11):2056-2066. (PMID: 23099487) (pdf)

Living matter – nexus of physics and biology in the 21st century. Gardel ML. Mol Biol Cell. 2012; 23:4165-4166. (PMID: 23112229) (pdf)

Self-Organization of Myosin II in Reconstituted Actomyosin Bundles. Stachowiak MR, McCall PM, Thoresen T, Balcioglu HE, Kasiewicz L, Gardel ML and O’Shaughnessy B. Biophys J. 2012;103:1265-1274. (PMID: 22995499) (pdf)

United we stand – integrating the actin cytoskeleton and cell-matrix adhesons in cellular mechanotransduction. Schwarz US and Gardel ML. J Cell Sci. 2012;125:1-10. (PMID: 22797913) (pdf)

Contractile units in disordered actomyosin bundles arise from F-actin buckling. Lenz M, Thoresen T, Gardel ML and Dinner AR. Phys Rev Lett. 2012;108:238107. (PMID: 23003998) (pdf)

Assembly kinetics determine the architecture of a-actinin crosslinked F-actin networks. Falzone TT, Lenz M, Kovar DR and Gardel ML. Nat Commun. 2012;3:861. (PMID: 22643888) (pdf)

Requirements for disordered actomyosin bundle contractility. Lenz M, Gardel ML and Dinner AR. New J Phys. 2012;14:033037. (link) (pdf)

Tension is required but not sufficient for focal adhesion maturation without a stress fiber template. Oakes PW, Beckham Y, Stricker J and Gardel ML. J Cell Biol. 2012;196(3):363-374. (PMID: 22291038) (pdf)
(Highlighted In Focus: Stress Fibers guide focal adhesions to maturity, selected for F1000 )


Spatiotemporal constraints on the force-dependent growth of focal adhesions. Stricker J, Aratyn-Schaus Y, Oakes PW and Gardel ML. Biophys J. 2011;100(12):2883-93. (PMID: 21689521) (pdf)

Reconstitution of contractile actomyosin bundles. Thoresen T, Lenz M, Gardel ML. Biophys J. 2011;100(11):2698-705. (PMID: 21641315) (pdf)

Dynamic and structural signatures of lamellar actomyosin force generation. Aratyn-Schaus Y, Oakes PW, Gardel ML. Mol Biol Cell. 2011;22:1330-1339. (PMID: 21307339) (pdf)

Cell-ECM traction force modulates endogenous tension at cell-cell contacts. Maruthamuthu V, Sabass B, Schwarz U. Gardel ML. Proc Natl Acad Sci U S A. 2011;12:4708-13. (PMID: 21383129) (pdf)
(selected for F1000 )

Shear thickening of F-actin networks crosslinked with non-muscle myosin IIB. Norstrom, M and Gardel, ML. Soft Matter. 2011 Jan 1;7:3228-3233. (pdf)


Preparation of compliant matrices for quantifying cellular contraction. Aratyn-Schaus Y, Oakes PW, Stricker J, Winter SP, Gardel ML. J Vis Exp. 2010 Dec 14;46. (PMID: 21178972) (pdf) (video)

A zyxin-mediated mechanism for actin stress fiber maintenance and repair. Smith MA, Blankman E, Gardel ML, Luettjohann L, Waterman CM, Beckerle MC. Dev Cell. 2010 Sep 14;19(3):365-76. (PMID: 20833360)

Conserved F-actin dynamics and force transmission at cell adhesions. Maruthamuthu V, Aratyn-Schaus Y, Gardel ML. Curr Opin Cell Biol. 2010 Oct;22(5):583-8. (PMID: 20728328)

Mechanical integration of actin and adhesion dynamics in cell migration. Gardel ML, Schneider IC, Aratyn-Schaus Y, Waterman CM. Annu Rev Cell Dev Biol. 2010 Nov 10;26:315-33. (PMID: 19575647)

Regulation of cell motile behavior by crosstalk between cadherin- and integrin-mediated adhesions. Borghi N, Lowndes M, Maruthamuthu V, Gardel ML, Nelson WJ. Proc Natl Acad Sci U S A. 2010 Jul 27;107(30):13324-9. (PMID: 20566866)

Transient frictional slip between integrin and the ECM in focal adhesions under myosin II tension. Aratyn-Schaus Y, Gardel ML. Curr Biol. 2010 Jul 13;20(13):1145-53. (PMID: 20541412) (pdf)
(in the same issue see also dispatch: Cell–Matrix Adhesion: Slip and Immobilization under Force. Verkhovsky AB. , selected for F1000)

Optimization of traction force microscopy for micron-sized focal adhesions. Stricker J, Sabass B, Schwarz US, Gardel ML. J Phys Condens Matter. 2010 Apr 26;22(19):194104. (PMID: 20523913) (pdf)

Mechanics of the F-actin cytoskeleton. Stricker J, Falzone T, Gardel ML. J Biomech. 2010 Jan 5;43(1):9-14. (PMID: 19913792) (pdf)


Identification and characterization of a small molecule inhibitor of formin-mediated actin assembly. Rizvi SA, Neidt EM, Cui J, Feiger Z, Skau CT, Gardel ML, Kozmin SA, Kovar DR. Chem Biol. 2009 Nov 25;16(11):1158-68. (PMID: 19942139) (pdf)
(selected for F1000 )

Local cortical tension by myosin II guides 3D endothelial cell branching. Fischer RS, Gardel M, Ma X, Adelstein RS, Waterman CM. Curr Biol. 2009 Feb 10;19(3):260-5. (PMID: 19185493)


Biophysics. Clutch dynamics. Aratyn-Schaus Y, Gardel ML. Science. 2008 Dec 12;322(5908):1646-7. (PMID: 19074337) (pdf)

Traction stress in focal adhesions correlates biphasically with actin retrograde flow speed. Gardel ML, Sabass B, Ji L, Danuser G, Schwarz US, Waterman CM. J Cell Biol. 2008 Dec 15;183(6):999-1005. (PMID: 19075110)
(see also commentary: The actin flow paradox.Williams R. JCB 2008 vol. 183 no. 6965)

Chapter 19: Mechanical response of cytoskeletal networks. Gardel ML, Kasza KE, Brangwynne CP, Liu J, Weitz DA. Methods Cell Biol. 2008;89:487-519. (PMID: 19118688) (pdf)

High resolution traction force microscopy based on experimental and computational advances. Sabass B, Gardel ML, Waterman CM, Schwarz US. Biophys J. 2008 Jan 1;94(1):207-20. (PMID: 17827246) (pdf)

PyK2 and FAK connections to p190Rho guanine nucleotide exchange factor regulate RhoA activity, focal adhesion formation, and cell motility. Lim Y, Lim ST, Tomar A, Gardel M, Bernard-Trifilo JA, Chen XL, Uryu SA, Canete-Soler R, Zhai J, Lin H, Schlaepfer WW, Nalbant P, Bokoch G, Ilic D, Waterman-Storer C, Schlaepfer DD. J Cell Biol. 2008 Jan 14;180(1):187-203. (PMID: 18195107) (pdf)


CD98hc (SLC3A2) participates in fibronectin matrix assembly by mediating integrin signaling. Féral CC, Zijlstra A, Tkachenko E, Prager G, Gardel ML, Slepak M, Ginsberg MH. J Cell Biol. 2007 Aug 13;178(4):701-11. (PMID: 17682053) (pdf)

Prestressed F-actin networks cross-linked by hinged filamins replicate mechanical properties of cells. Gardel ML, Nakamura F, Hartwig JH, Crocker JC, Stossel TP, Weitz DA. Proc Natl Acad Sci U S A. 2006 Feb 7;103(6):1762-7. (PMID: 16446458) (pdf)

Stress-dependent elasticity of composite actin networks as a model for cell behavior. Gardel ML, Nakamura F, Hartwig J, Crocker JC, Stossel TP, Weitz DA. Phys Rev Lett. 2006 Mar 3;96(8):088102. (PMID: 16606229) (pdf)

Microrheology probes length scale dependent rheology. Liu J, Gardel ML, Kroy K, Frey E, Hoffman BD, Crocker JC, Bausch AR, Weitz DA. Phys Rev Lett. 2006 Mar 24;96(11):118104. (PMID: 16605878) (pdf)

Scaling of F-actin network rheology to probe single filament elasticity and dynamics. Gardel ML, Shin JH, MacKintosh FC, Mahadevan L, Matsudaira PA, Weitz DA. Phys Rev Lett. 2004 Oct 29;93(18):188102. (PMID: 15525211) (pdf)

Elastic behavior of cross-linked and bundled actin networks. Gardel ML, Shin JH, MacKintosh FC, Mahadevan L, Matsudaira P, Weitz DA. Science. 2004 May 28;304(5675):1301-5. (PMID: 15166374) (pdf)

Relating microstructure to rheology of a bundled and cross-linked F-actin network in vitro. Shin JH, Gardel ML, Mahadevan L, Matsudaira P, Weitz DA. Proc Natl Acad Sci U S A. 2004 Jun 29;101(26):9636-41. (PMID: 15210969) (pdf)

Colloid surface chemistry critically affects multiple particle tracking measurements of biomaterials. Valentine MT, Perlman ZE, Gardel ML, Shin JH, Matsudaira P, Mitchison TJ, Weitz DA. Biophys J. 2004 Jun;86(6):4004-14. (PMID: 15189896) (pdf)

Anomalous diffusion probes microstructure dynamics of entangled F-actin networks. Wong IY, Gardel ML, Reichman DR, Weeks ER, Valentine MT, Bausch AR, Weitz DA. Phys Rev Lett. 2004 Apr 30;92(17):178101. (PMID: 15169197) (pdf)

Microrheology of entangled F-actin solutions. Gardel ML, Valentine MT, Crocker JC, Bausch AR, Weitz DA. Phys Rev Lett. 2003 Oct 10;91(15):158302. (PMID: 14611506) (pdf)

Microrheology. Gardel ML, Valentine MT, Weitz DA. Microscale Diagnostic Techniques. 2005 K. Breuer (ed) Springer Verlag. (pdf)

Measuring the mechanical stress induced by an expanding multicellular tumor system: a case study. Gordon VD, Valentine MT, Gardel ML, Andor-Ardó D, Dennison S, Bogdanov AA, Weitz DA, Deisboeck TS. Exp Cell Res. 2003 Sep 10;289(1):58-66. (PMID: 12941604) (pdf)

Giant dielectric constant response in a copper-titanate. Ramirez AP, Subramanian MA, Gardel M, Blumberg G, Li D, Vogt T, Shapiro SM. Solid State Commun. 2000;115:217-220.

Electron detachment and fragmentation in collisions between 1.25 keV/carbon C8- and C60- clusters and H2. Gardel ML, Vandenbosch R, Henry BP, Cooper C, Will DI. Eur Phys J D. 1999;7:79-81.

Long wavelength spin dynamics in La0.53Ca0.47MnO3. Rhyne JJ, Kaiser H, Luo H, Xiao G, and Gardel ML. J Appl Phys. 1998;83:7339-7341.

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