Gardel Lab Publications

2017  I   2016  I  2015  I  2014  I  2013  I  2012  I  2011  I   2010  I  2009  I  2008  I  Pre-2007

 

2017

Cholesterol depletion impairs contractile machinery in neonatal rat cardiomyocytes. Hissa B, Oakes PW, Pontes B, Ramirez-San Juan GR, Gardel ML. Sci Rep. 2017; 7:43764. (link)

Contact guidance requires spatial control of leading edge protrusion. Ramirez-San Juan GR, Oakes PW, Gardel ML. Mol Biol Cell; 2017. (link)

Harnessing optogenetics to probe sub-cellular mechanics. Oakes PW, Wagner E, Brand CA, Probst D, Linke M, Schwarz US, Glotzer M, Gardel ML. Under review.; 2017. (bioRxiv)

Liquid behavior of cross-linked actin bundles. Weirich KL, Banerjee S, Disbiswas K, Witten TA, Vaikuntanathan S, and Gardel ML. Proc Natl Acad Sci USA. 2017; 114(9):2131-2136. (link)

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2016

Cycling State that Can Lead to Glassy Dynamics in Intracellular Transport. Scholz M, Burov S, Weirich KL, Scholz BJ, Tabei SMA, Gardel ML and Dinner AR. Phys Rev. X 2016; (6):011037. (link) (pdf)

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2015

Measuring Cell Mechanics. Gardel M & Oakes P. Colloquium Series on Quantitative Cell Biology: Vol. 3 ed. Marshall WF. Morgan & Claypool Life Sciences Publishers. 2015; DOI: 10.4199/C00137ED1V01Y201508QCB003 (Link)

Forcing cells into shape: the mechanics of actomyosin contractility. Murrell M, Oakes PW, Lenz M and Gardel ML. Nat Rev Mol Cell Biol. 2015; 16(8):486-498. (PMID:26130009) (pdf)

Model for adhesion clutch explains biphasic relationship between actin flow and traction at the cell leading edge. Craig EM, Stricker J, Gardel M and Mogilner A. Phys Biol. 2015; 12(3):035002. (PMID:25969948) (pdf)

Actin mechanics and fragmentation. De La Cruz EM and Gardel ML. J Biol Chem. 2015; 290(28):17137-44 (PMID:25957404) (pdf)

Isoforms Confer Characteristic Force Generation and Mechanosensation by Myosin II Filaments. Stam S, Alberts J, Gardel ML, and Munro E. Biophys J. 2015; 108(8):1997-2006. (PMID:25902439) (pdf)

Model-based traction force microscopy reveals differential tension in cellular actin bundles. Soiné JRD, Brand CA, Stricker J, Oakes PW, Gardel ML, Schwarz US. PLoS Comput Biol. 2015; 11(3):e1004076. (PMID:25748431) (pdf)

iBiology - Margaret Gardel: What is Cytoplasm? (iBiology) (YouTube) (iTunes)

Moving beyond molecular mechanisms. Gardel ML. J Cell Biol. 2015; 208(2):143-145. (PMID:25601400) (pdf)

Attenuation of LPS-induced Lung Vascular Stiffening by Lipoxin Reduces Lung Inflammation. Meng F, Mambetsariev I, Tian Y, Beckham Y, Meliton A, Leff A, Gardel ML, Allen MJ, Birukov KG and Birukov AA. Am J Respir Cell Mol Biol. 2015; 52(2):152-161. (PMID:24992633) (pdf)

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2014

Epithelial rotation promotes the global alignment of contractile actin bundles during Drosophila egg chamber elongation. Cetera M, Ramirez-San Juan GR, Oakes PW, Lewellyn L, Fairchild MJ, Tanentzapf G, Gardel ML, Horne-Badovinac S. Nat. Commun. 2014; 5:1-12 (PMID: 25413675) (pdf)

Cutting through the noise: the mechanics of intracellular transport. Stam S and Gardel ML. Dev Cell. 2014; 30:365-366. (PMID:25158851) (pdf)

Geometry Regulates Traction Stresses in Adherent Cells. Oakes PW, Banerjee S, Marchetti CM and Gardel ML. Biophys J. 2014; 107(4):825-833. (PMID:25140417) (pdf)
(In the same issue see New and Notable: Work and Tension: New Evidence that Adherent Cells of Same Area Do the Same Work Independent of Stiffness and Focal Adhesions. Pok S & Jacot JG.)

Protrusive Activity Guides Changes in Cell-Cell Tension during Epithelial Cell Scattering. Maruthamuthu V and Gardel ML. Biophys J. 2014; 107(3):555-563. (PMID:25099795) (pdf)

Stressing the Limits of Focal Adhesion Mechanosensitivity. Oakes PW and Gardel ML. Curr Opin Cell Biol. 2014; 30:68-73. (PMID:24998185) (pdf)

Arp2/3 Inhibition Induces Amoeboid-Like Protrusions in MCF10A Epithelial Cells by Reduced Cytoskeletal-Membrane Coupling and Focal Adhesion Assembly. Beckham Y, Vasquez RJ, Stricker J, Sayegh K, Campillo C and Gardel ML. PLoS ONE. 2014; 9(6):e100943. (PMID:24967897) (pdf)

Actomyosin Sliding is Attenuated in Contractile Biomimetic Cortices. Murrell M and Gardel ML. Mol Biol Cell. 2014; 25(12):1845-53. (PMID:24760970) (pdf)

Reconstitution of Contractile Actomyosin Arrays. Murrell M, Thoresen T and Gardel ML. Methods Enzymol 2014; 540:265-82. (PMID:24630112) (pdf)

Determinants of Fluid-like Behavior and Effective Viscosity in Cross-linked Actin Networks. Kim TY, Gardel ML and Munro E. Biophys J. 2014; 106(3):526-534. (PMID:24507593) (pdf)

Liposome Adhesion Generates Traction Stress. Murrell MP, Voituriez R, Joanny J-F, Nassoy P, Sykes C and Gardel ML. Nat Phys. 2014; 10:163-169. (link) (pdf)

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2013

Distribution of Directional Change as a Signature of Complex Dynamics. Burov  S, Tabei SMA, Huynh T, Murrell MP, Philipson LH, Rice SA, Gardel ML, Scherer NF and Dinner AR. Proc Natl Acad Sci USA. 2013; 110(49):19689-19694. (PMID:24248363) (pdf)

Endothelial Barrier Disruption and Recovery is Controlled by Substrate Stiffness. Birukova AA, Tian X, Cokic I, Beckham Y, Gardel ML and Birukov KG. Microvasc Res. 2013; 87:50-57. (PMID:23296034) (pdf)

Myosin II-Mediated Focal Adhesion Maturation Is Tension Insensitive. Stricker J, Beckham Y, Davidson MW and Gardel ML. PLoS ONE. 2013; 8(7):e70652. (PMID:23923013) (pdf)

Actin assembly factors regulate the gelation kinetics and architecture of F-actin networks. Falzone TT, Oakes PW, Sees J, Kovar DR and Gardel ML. Biophys J. 2013; 104(8):1709-1719. (PMID:23601318) (pdf)

Thick filament length and isoform composition determine self-organized contractile units in actomyosin bundles. Thoresen T, Lenz M and Gardel ML. Biophys J. 2013; 104(11):655-665. (PMID: 23442916) (pdf)

Materials science: Synthetic polymers with biological rigidity. Gardel ML, Nature. 2013; 493:618-619. (PMID: 23354043) (pdf)

Observation and characterization of the vestige of the jamming transition in a thermal three-dimensional system. Caswell TA, Zhang Z, Gardel ML and Nagel SR, Phys Rev E. 2013; 87(1):012303. (PMID: 23410327) (pdf)

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2012

F-actin buckling coordinates contractility and severing in a biomimetic actomyosin cortex. Murrell MP and Gardel ML, Proc Natl Acad Sci USA. 2012; 109(51):20820-20825. (PMID: 23213249) (pdf)

Stiffness-controlled three-dimensional extracellular matrices for high-resolution imaging of cell behavior. Fischer RS, Myers KA, Gardel ML and Waterman CM, Nat Protoc. 2012; 7(11):2056-2066. (PMID: 23099487) (pdf)

Living matter - nexus of physics and biology in the 21st century. Gardel ML. Mol Biol Cell. 2012; 23:4165-4166. (PMID: 23112229) (pdf)

Self-Organization of Myosin II in Reconstituted Actomyosin Bundles. Stachowiak MR, McCall PM, Thoresen T, Balcioglu HE, Kasiewicz L, Gardel ML and O'Shaughnessy B. Biophys J. 2012;103:1265-1274. (PMID: 22995499) (pdf)

United we stand - integrating the actin cytoskeleton and cell-matrix adhesons in cellular mechanotransduction. Schwarz US and Gardel ML. J Cell Sci. 2012;125:1-10. (PMID: 22797913) (pdf)

Contractile units in disordered actomyosin bundles arise from F-actin buckling. Lenz M, Thoresen T, Gardel ML and Dinner AR. Phys Rev Lett. 2012;108:238107. (PMID: 23003998) (pdf)

Assembly kinetics determine the architecture of a-actinin crosslinked F-actin networks. Falzone TT, Lenz M, Kovar DR and Gardel ML. Nat Commun. 2012;3:861. (PMID: 22643888) (pdf)

Requirements for disordered actomyosin bundle contractility. Lenz M, Gardel ML and Dinner AR. New J Phys. 2012;14:033037. (link) (pdf)

Tension is required but not sufficient for focal adhesion maturation without a stress fiber template. Oakes PW, Beckham Y, Stricker J and Gardel ML. J Cell Biol. 2012;196(3):363-374. (PMID: 22291038) (pdf)
(Highlighted In Focus: Stress Fibers guide focal adhesions to maturity, selected for F1000 )

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2011

Spatiotemporal constraints on the force-dependent growth of focal adhesions. Stricker J, Aratyn-Schaus Y, Oakes PW and Gardel ML. Biophys J. 2011;100(12):2883-93. (PMID: 21689521) (pdf)

Reconstitution of contractile actomyosin bundles. Thoresen T, Lenz M, Gardel ML. Biophys J. 2011;100(11):2698-705. (PMID: 21641315) (pdf)

Dynamic and structural signatures of lamellar actomyosin force generation. Aratyn-Schaus Y, Oakes PW, Gardel ML. Mol Biol Cell. 2011;22:1330-1339. (PMID: 21307339) (pdf)

Cell-ECM traction force modulates endogenous tension at cell-cell contacts. Maruthamuthu V, Sabass B, Schwarz U. Gardel ML. Proc Natl Acad Sci U S A. 2011;12:4708-13. (PMID: 21383129) (pdf)
(selected for F1000 )

Shear thickening of F-actin networks crosslinked with non-muscle myosin IIB. Norstrom, M and Gardel, ML. Soft Matter. 2011 Jan 1;7:3228-3233. (pdf)

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2010

Preparation of compliant matrices for quantifying cellular contraction. Aratyn-Schaus Y, Oakes PW, Stricker J, Winter SP, Gardel ML. J Vis Exp. 2010 Dec 14;46. (PMID: 21178972) (pdf) (video)

A zyxin-mediated mechanism for actin stress fiber maintenance and repair. Smith MA, Blankman E, Gardel ML, Luettjohann L, Waterman CM, Beckerle MC. Dev Cell. 2010 Sep 14;19(3):365-76. (PMID: 20833360)

Conserved F-actin dynamics and force transmission at cell adhesions. Maruthamuthu V, Aratyn-Schaus Y, Gardel ML. Curr Opin Cell Biol. 2010 Oct;22(5):583-8. (PMID: 20728328)

Mechanical integration of actin and adhesion dynamics in cell migration. Gardel ML, Schneider IC, Aratyn-Schaus Y, Waterman CM. Annu Rev Cell Dev Biol. 2010 Nov 10;26:315-33. (PMID: 19575647)

Regulation of cell motile behavior by crosstalk between cadherin- and integrin-mediated adhesions. Borghi N, Lowndes M, Maruthamuthu V, Gardel ML, Nelson WJ. Proc Natl Acad Sci U S A. 2010 Jul 27;107(30):13324-9. (PMID: 20566866)

Transient frictional slip between integrin and the ECM in focal adhesions under myosin II tension. Aratyn-Schaus Y, Gardel ML. Curr Biol. 2010 Jul 13;20(13):1145-53. (PMID: 20541412) (pdf)
(in the same issue see also dispatch: Cell–Matrix Adhesion: Slip and Immobilization under Force. Verkhovsky AB. , selected for F1000)

Optimization of traction force microscopy for micron-sized focal adhesions. Stricker J, Sabass B, Schwarz US, Gardel ML. J Phys Condens Matter. 2010 Apr 26;22(19):194104. (PMID: 20523913) (pdf)

Mechanics of the F-actin cytoskeleton. Stricker J, Falzone T, Gardel ML. J Biomech. 2010 Jan 5;43(1):9-14. (PMID: 19913792) (pdf)

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2009

Identification and characterization of a small molecule inhibitor of formin-mediated actin assembly. Rizvi SA, Neidt EM, Cui J, Feiger Z, Skau CT, Gardel ML, Kozmin SA, Kovar DR. Chem Biol. 2009 Nov 25;16(11):1158-68. (PMID: 19942139) (pdf)
(selected for F1000 )

Local cortical tension by myosin II guides 3D endothelial cell branching. Fischer RS, Gardel M, Ma X, Adelstein RS, Waterman CM. Curr Biol. 2009 Feb 10;19(3):260-5. (PMID: 19185493)

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2008

Biophysics. Clutch dynamics. Aratyn-Schaus Y, Gardel ML. Science. 2008 Dec 12;322(5908):1646-7. (PMID: 19074337) (pdf)

Traction stress in focal adhesions correlates biphasically with actin retrograde flow speed. Gardel ML, Sabass B, Ji L, Danuser G, Schwarz US, Waterman CM. J Cell Biol. 2008 Dec 15;183(6):999-1005. (PMID: 19075110)
(see also commentary: The actin flow paradox.Williams R. JCB 2008 vol. 183 no. 6965)

Chapter 19: Mechanical response of cytoskeletal networks. Gardel ML, Kasza KE, Brangwynne CP, Liu J, Weitz DA. Methods Cell Biol. 2008;89:487-519. (PMID: 19118688) (pdf)

High resolution traction force microscopy based on experimental and computational advances. Sabass B, Gardel ML, Waterman CM, Schwarz US. Biophys J. 2008 Jan 1;94(1):207-20. (PMID: 17827246) (pdf)

PyK2 and FAK connections to p190Rho guanine nucleotide exchange factor regulate RhoA activity, focal adhesion formation, and cell motility. Lim Y, Lim ST, Tomar A, Gardel M, Bernard-Trifilo JA, Chen XL, Uryu SA, Canete-Soler R, Zhai J, Lin H, Schlaepfer WW, Nalbant P, Bokoch G, Ilic D, Waterman-Storer C, Schlaepfer DD. J Cell Biol. 2008 Jan 14;180(1):187-203. (PMID: 18195107) (pdf)

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Pre-2007

CD98hc (SLC3A2) participates in fibronectin matrix assembly by mediating integrin signaling. Féral CC, Zijlstra A, Tkachenko E, Prager G, Gardel ML, Slepak M, Ginsberg MH. J Cell Biol. 2007 Aug 13;178(4):701-11. (PMID: 17682053) (pdf)

Prestressed F-actin networks cross-linked by hinged filamins replicate mechanical properties of cells. Gardel ML, Nakamura F, Hartwig JH, Crocker JC, Stossel TP, Weitz DA. Proc Natl Acad Sci U S A. 2006 Feb 7;103(6):1762-7. (PMID: 16446458) (pdf)

Stress-dependent elasticity of composite actin networks as a model for cell behavior. Gardel ML, Nakamura F, Hartwig J, Crocker JC, Stossel TP, Weitz DA. Phys Rev Lett. 2006 Mar 3;96(8):088102. (PMID: 16606229) (pdf)

Microrheology probes length scale dependent rheology. Liu J, Gardel ML, Kroy K, Frey E, Hoffman BD, Crocker JC, Bausch AR, Weitz DA. Phys Rev Lett. 2006 Mar 24;96(11):118104. (PMID: 16605878) (pdf)

Scaling of F-actin network rheology to probe single filament elasticity and dynamics. Gardel ML, Shin JH, MacKintosh FC, Mahadevan L, Matsudaira PA, Weitz DA. Phys Rev Lett. 2004 Oct 29;93(18):188102. (PMID: 15525211) (pdf)

Elastic behavior of cross-linked and bundled actin networks. Gardel ML, Shin JH, MacKintosh FC, Mahadevan L, Matsudaira P, Weitz DA. Science. 2004 May 28;304(5675):1301-5. (PMID: 15166374) (pdf)

Relating microstructure to rheology of a bundled and cross-linked F-actin network in vitro. Shin JH, Gardel ML, Mahadevan L, Matsudaira P, Weitz DA. Proc Natl Acad Sci U S A. 2004 Jun 29;101(26):9636-41. (PMID: 15210969) (pdf)

Colloid surface chemistry critically affects multiple particle tracking measurements of biomaterials. Valentine MT, Perlman ZE, Gardel ML, Shin JH, Matsudaira P, Mitchison TJ, Weitz DA. Biophys J. 2004 Jun;86(6):4004-14. (PMID: 15189896) (pdf)

Anomalous diffusion probes microstructure dynamics of entangled F-actin networks. Wong IY, Gardel ML, Reichman DR, Weeks ER, Valentine MT, Bausch AR, Weitz DA. Phys Rev Lett. 2004 Apr 30;92(17):178101. (PMID: 15169197) (pdf)

Microrheology of entangled F-actin solutions. Gardel ML, Valentine MT, Crocker JC, Bausch AR, Weitz DA. Phys Rev Lett. 2003 Oct 10;91(15):158302. (PMID: 14611506) (pdf)

Microrheology. Gardel ML, Valentine MT, Weitz DA. Microscale Diagnostic Techniques. 2005 K. Breuer (ed) Springer Verlag. (pdf)

Measuring the mechanical stress induced by an expanding multicellular tumor system: a case study. Gordon VD, Valentine MT, Gardel ML, Andor-Ardó D, Dennison S, Bogdanov AA, Weitz DA, Deisboeck TS. Exp Cell Res. 2003 Sep 10;289(1):58-66. (PMID: 12941604) (pdf)

Giant dielectric constant response in a copper-titanate. Ramirez AP, Subramanian MA, Gardel M, Blumberg G, Li D, Vogt T, Shapiro SM. Solid State Commun. 2000;115:217-220.

Electron detachment and fragmentation in collisions between 1.25 keV/carbon C8- and C60- clusters and H2. Gardel ML, Vandenbosch R, Henry BP, Cooper C, Will DI. Eur Phys J D. 1999;7:79-81.

Long wavelength spin dynamics in La0.53Ca0.47MnO3. Rhyne JJ, Kaiser H, Luo H, Xiao G, and Gardel ML. J Appl Phys. 1998;83:7339-7341.

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